N-isopropyl-2-nitrobenzenesulfonamide → 2-Amino-N-isopropylbenzenesulfonamide

HRID 1887710ノート

反応式

HRID 1887710 の反応式
[CH:1]([NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N+:14]([O-])=O)(=[O:7])=[O:6])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[S:5]([NH:4][CH:1]([CH3:3])[CH3:2])(=[O:7])=[O:6]

参加物

5

反応物 2

HCID 4154456N-isopropyl-2-nitrobenzenesulfonamideHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 167834652-Amino-N-isopropylbenzenesulfonamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To N-isopropyl-2-nitrobenzenesulfonamide (774 mg) in methanol (50 mL) was added Pd/C (10% Pd in carbon, 150 mg, 19 wt %) under argon protection. A hydrogen balloon was used as the hydrogen source. The reaction was stirred at room temperature overnight. The mixture was filtered through celite and the celite pad was washed several times. The solvent was removed and the crude was purified by silica gel chromatography to obtain the desired product 2-amino-N-isopropylbenzenesulfonamide (quantitative yield).

後処理

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was washed several times
  3. customThe solvent was removed
  4. customthe crude was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-ad18248975df4150a1fb470bd327ec34
出典データセット
uspto-grants-2013_08
特許番号
US08501763B2

反応ノート

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