Chloroacetyl chloride → 2-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide

HRID 1887714ノート

反応式

HRID 1887714 の反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.[OH-].[K+]>CCOC(C)=O.O>[Cl:1][CH2:2][C:3]([N:7]([CH3:6])[C:8]1[CH:9]=[CH:10][C:11]([N+:14]([O-:16])=[O:15])=[CH:12][CH:13]=1)=[O:4]

参加物

6

反応物 3

HCID 6577Chloroacetyl chlorideHCID 7483N-Methyl-4-nitroanilineHCID 14797Potassium Hydroxide

生成物 1

HCID 114361292-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
0 °C

実験手順

Chloroacetyl chloride (1.05 mL, 13.1 mmol) is added in one portion to a biphasic mixture of N-methyl-4-nitroaniline (1.0 g, 6.57 mmol), KOH (1.11 g, 19.7 mmol) in 12 mL EtOAc and 12 mL H2O, cooled to 0° C. The resulting mixture is stirred at this temperature for 5 min, then the ice bath was removed and it was allowed to warm to RT. The reaction was stirred for an additional one hour at RT.

後処理

  1. customthe ice bath was removed
  2. temperatureto warm to RT
  3. stirringThe reaction was stirred for an additional one hour at RT

出典と根拠

ORDレコード
ord-7ea943c4ff404856983585c5322e5957
出典データセット
uspto-grants-2013_08
特許番号
US08501763B2

反応ノート

読み込み中…