Donepezil → Donepezil Maleate

HRID 1888064

反応式

HRID 1888064 の反応式
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[CH2:22][CH:21]([CH2:23][CH:24]3[CH2:29][CH2:28][N:27]([CH2:30][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:26][CH2:25]3)[C:19](=[O:20])[C:14]2=[CH:15][C:16]=1[O:17][CH3:18].C(OCCC)CC>C(OCC)(=O)C>[CH3:9][O:10][C:11]1[CH:12]=[C:13]2[CH2:22][CH:21]([CH2:23][CH:24]3[CH2:25][CH2:26][N:27]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[CH2:28][CH2:29]3)[C:19](=[O:20])[C:14]2=[CH:15][C:16]=1[O:17][CH3:18].[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([O-:6])=[O:5]

参加物

5

反応物 3

HCID 3152DonepezilHCID 8114Propyl etherHCID 444266Maleic Acid

生成物 1

HCID 24801486Donepezil Maleate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Maleic acid (1.161 g, dissolved in 10 ml of 2-propanol) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (20 ml) with stirring at room temperature followed by adding 10 ml of dipropyl ether. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 126.8° C.

後処理

  1. customThe solid precipitated
  2. filtrationis filtered
  3. customdried at 55° C. under vacuum

出典と根拠

ORDレコード
ord-32da11b15fde4c9cb03ca14a19bc2d79
出典データセット
uspto-grants-2013_08
特許番号
US08501779B2

関連ノート

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