Flunixin Meglumine → Flunixin

HRID 1888133

反応式

HRID 1888133 の反応式
[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:21])([F:20])[F:19].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>O>[CH3:1][C:2]1[C:7]([NH:8][C:9]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([OH:17])=[O:16])=[CH:6][CH:5]=[CH:4][C:3]=1[C:18]([F:20])([F:19])[F:21]

参加物

3

反応物 1

HCID 39212Flunixin Meglumine

生成物 1

HCID 38081Flunixin収率 90%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5 L of water is added to about 500 g of Banamine Paste while maintaining the temperature at less than 30° C. The resulting mixture was agitated for about 3 hours while continuing to maintain the temperature at less than 30° C. The resulting precipitate was removed by filtration. The filtered solids were washed with about 1 L of water and the pH of the filtrate was adjusted to 4-5 with aqueous citric acid solution (50%). The precipitated Flunixin was collected by filtration and washed with 0.5 L of water, then dried at about 50-60° C. to a moisture content of less than 1% to yield about 22.4 g of crude Flunixin (90%).

後処理

  1. temperaturewhile maintaining the temperature at less than 30° C
  2. temperatureto maintain the temperature at less than 30° C
  3. customThe resulting precipitate was removed by filtration
  4. washThe filtered solids were washed with about 1 L of water
  5. filtrationThe precipitated Flunixin was collected by filtration
  6. washwashed with 0.5 L of water
  7. customdried at about 50-60° C. to a moisture content of less than 1%

出典と根拠

ORDレコード
ord-583a84d428ef48bc9999dbd26694038f
出典データセット
uspto-grants-2013_08
特許番号
US08501788B2

関連ノート

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