Flunixin Meglumine

HCID 39212CAS 42461-84-7

基本情報

標準SMILES: CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F
InChIKey: MGCCHNLNRBULBU-WZTVWXICSA-N
分子式: C21H28F3N3O7
平均分子量: 491.5 g/mol

概要

Flunixin meglumine is an organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It contains a flunixin(1-).

名称と識別子

優先名称: Flunixin Meglumine
IUPAC: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid

名称と別名

FLUNIXIN MEGLUMINE42461-84-7BanamineFlumeglumineSch 14714 meglumineFlunixin-SFlunixin N-methylglucanineSch-14714 meglumine8Y3JK0JW3UFlunixin meglumine saltFlunazineNSC-759583

名称をさらに表示

CHEBI:761442-((2-Methyl-3-(trifluoromethyl)-phenyl)amino)-3-pyridinecarboxylic acid with meglumine compoundedDTXCID9025584FlunineVetaMegBanamine PasteFlunazine-SVetameg S

データベース識別子

CAS: 42461-84-7
PubChem CID: 39212
ChEMBL: CHEMBL1733447
ChEBI: CHEBI:76144
UNII: 8Y3JK0JW3U
EC Number: 255-836-0

物性

構造計算による物性

極性表面積: 175 Å²
水素結合供与体数: 8
水素結合受容体数: 13
回転可能結合数: 9
重原子数: 34
形式電荷: 0
複雑度: 510

実験および物理化学的性質

DrugsDEA NFLIS-Drug Category -> Analgesics

Animal DrugsActive Ingredients (Flunixin Meglumine) -> FDA Greenbook

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 0.5% (1 of 215) of reports.

Danger

H301 (79.5%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 215 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationFlunixin meglumine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - D-Glucitol, 1-deoxy-1-(methylamino)-, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate (salt): Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 3 (79.5%)

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Drugs that are used to reduce body temperature in fever.