Potassium Hydroxide → HCID 178451813、化合物

HRID 1888208ノート

反応式

HRID 1888208 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O-:21])=[O:20])[CH2:15][CH2:14]1.[OH-:22].[K+]>CC(O)(C)C>[NH2:12][C:11]([C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]2[C:8]=1[NH:7][N:6]=[C:5]2[CH:13]1[CH2:14][CH2:15][N:16]([C:19]([O:21][C:4]([CH3:8])([CH3:5])[CH3:3])=[O:20])[CH2:17][CH2:18]1)=[O:22]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 178509435HCID 178509435、化合物

生成物 1

HCID 178451813HCID 178451813、化合物収率 191.5%

試薬・触媒・溶媒 1

HCID 6386tert-Butanol溶媒

実験手順

To 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (0.30 g, 0.74 mmols) in 2-methyl-2-propanol (30 mL) was added KOH (0.45 g, 7.4 mmol). The reaction mixture was heated at reflux overnight. After cooling, the solvent was evaporated and the residue was redissovled in ethyl acetate (150 mL) and filtered through a pad of silica gel to give the title compound (300 mg) as a yellow solid (99%).

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux overnight
  3. temperatureAfter cooling
  4. customthe solvent was evaporated
  5. filtrationfiltered through a pad of silica gel

出典と根拠

ORDレコード
ord-6f971cba14fc424a903f576721d2ba23
出典データセット
uspto-grants-2013_08
特許番号
US08501780B2

反応ノート

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