Trifluoroacetic acid → HCID 178509434、化合物

HRID 1888211ノート

反応式

HRID 1888211 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1.FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 178451811HCID 178451811、化合物2 回

生成物 1

HCID 178509434HCID 178509434、化合物収率 147.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1,1-dimethylethyl 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (Intermediate 3) (0.200 g, 0.493 mmols) and trifluoroacetic acid (0.25 mL) in dichloromethane (5 mL) was stirred at room temperature for 2 hrs. The solution was cooled and the solvent removed in vacuo to give the crude amine (222 mg) trifluoroacetate salt, which was used in the next step without further purification.

後処理

  1. temperatureThe solution was cooled
  2. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-fb808721c9014c93b9d0ec8234f112cf
出典データセット
uspto-grants-2013_08
特許番号
US08501780B2

反応ノート

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