Triethylamine → HCID 178477699、化合物

HRID 1888277

反応式

HRID 1888277 の反応式
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[C:12]([C:23]([NH2:25])=[O:24])[CH:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1.[CH2:26]([S:28](Cl)(=[O:30])=[O:29])[CH3:27].C(N(CC)CC)C>C(Cl)Cl>[CH2:26]([S:28]([N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[C:12]([C:23]([NH2:25])=[O:24])[CH:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1)(=[O:30])=[O:29])[CH3:27]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 11667Ethanesulfonyl chlorideHCID 178479540HCID 178479540、化合物2 回

生成物 1

HCID 178477699HCID 178477699、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

This compound was prepared in a fashion analogous to the procedure described in Example 3. Thus 3-(4-piperidinyl)-5-(3-pyridinyl)-1H-indazole-7-carboxamide hydrochloride (Intermediate 21) (0.09 mmol) was reacted with ethane sulfonyl chloride (0.01 mL, 0.217 mmol) in the presence of triethylamine (0.04 mL, 0.468 mmol) in methylene chloride (10 mL) to give the title compound (4.9 mg, 13% for the last two steps)

後処理

  1. customThis compound was prepared in a fashion analogous to the procedure

出典と根拠

ORDレコード
ord-06aebaefeaeb4ed088fcd0e4819e3401
出典データセット
uspto-grants-2013_08
特許番号
US08501780B2

関連ノート

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