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Hydrochloric Acid → 2-[(2-{(4S)-4-[(1E,3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid

HRID 1888298
ノート
印刷プレビュー

反応式

HRID 1888298 の反応式
[OH:1][C@@H:2]([C:24]([CH3:30])([CH3:29])[CH2:25][CH2:26][CH2:27][CH3:28])/[CH:3]=[CH:4]/[C@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[CH2:11][CH2:12][S:13][C:14]1[S:15][CH:16]=[C:17]([C:19]([O:21]CC)=[O:20])[N:18]=1.[OH-].[Na+].Cl>CO>[OH:1][C@@H:2]([C:24]([CH3:29])([CH3:30])[CH2:25][CH2:26][CH2:27][CH3:28])/[CH:3]=[CH:4]/[C@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[CH2:11][CH2:12][S:13][C:14]1[S:15][CH:16]=[C:17]([C:19]([OH:21])=[O:20])[N:18]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66857441ethyl 2-[(2-{(4S)-4-[(1E,3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)thio]-1,3-thiazole-4-carboxylate

生成物 1

HCID 595548242-[(2-{(4S)-4-[(1E,3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-2-oxo-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid収率 100%

試薬・触媒・溶媒 1

HCID 887
Methanol
溶媒

実験手順

To a solution of the compound 7 (84.0 mg) in methanol (1.00 mL) was added an aqueous solution of 2N sodium hydroxide (0.19 mL) at 0° C. and the solution was stirred at room temperature for 1 hour. To the reaction solution was added an aqueous solution of 2N hydrochloric acid (0.30 mL). The solution was extracted with ethyl acetate and washed with water and brine. The reaction solution was dried over anhydrous sodium sulfate and concentrated to give the title compound (78.8 mg) having the following physical data.

後処理

  1. extractionThe solution was extracted with ethyl acetate
  2. washwashed with water and brine
  3. dry with materialThe reaction solution was dried over anhydrous sodium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-b16b1308d8a642e4900da7eb11e458c4
出典データセット
uspto-grants-2013_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08501793B2

反応ノート

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