Water → 5-(Hydroxymethyl)-2-iodophenol
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5](O)=[O:6].B.C1COCC1.O>C1COCC1>[OH:6][CH2:5][C:4]1[CH:8]=[CH:9][C:10]([I:11])=[C:2]([OH:1])[CH:3]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a solution of 3-hydroxy-4-iodobenzoic acid (20.9 g, 79.3 mmol) in anhydrous THF (160 mL) was added 1 M borane THF solution (240 mL, 240 mmol) by small portions, and the mixture was stirred at 60° C. for 2 hr. Water was added to the reaction mixture, and the mixture was extracted twice with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was washed with diisopropyl ether and hexane to give the title compound (17.4 g, yield 88%) as a white solid.
後処理
- extractionthe mixture was extracted twice with ethyl acetate
- washThe extract was washed with saturated brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated under reduced pressure
- washthe residue was washed with diisopropyl ether and hexane
出典と根拠
- ORDレコード
- ord-b8e881aa9c4f4ab0a87d087b2603073a
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08501804B2
反応ノート
読み込み中…