Iodoethane → 3-Bromo-4-ethoxybenzyl alcohol

HRID 1888767ノート

反応式

HRID 1888767 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[OH:10].I[CH2:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:12][CH3:13]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 1215942-Bromo-4-hydroxymethylphenol

生成物 1

HCID 580476873-Bromo-4-ethoxybenzyl alcohol収率 87.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-bromo-4-(hydroxymethyl)phenol (3.00 g, 14.7 mmol), iodoethane (4.60 mL, 44.3 mmol) and potassium carbonate (6.12 g, 44.3 mmol) in ethanol (30 mL) was stirred at room temperature for 2 days. The obtained reaction mixture was filtered through celite, and the solvent was evaporated under reduced pressure. The residue was applied to silica gel chromatography (ethyl acetate). The solvent was evaporated under reduced pressure to give (3-bromo-4-ethoxyphenyl)methanol (2.98 g) as a white solid.

後処理

  1. customThe obtained reaction mixture
  2. filtrationwas filtered through celite
  3. customthe solvent was evaporated under reduced pressure
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-825de0de19a44d139f4af8e76ce0f888
出典データセット
uspto-grants-2013_08
特許番号
US08501804B2

反応ノート

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