Hydrochloric Acid → [5-(Methanesulfonyl)pyridin-2-yl]methanaminium chloride

HRID 1888829ノート

反応式

HRID 1888829 の反応式
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[N:12])=[N:9][CH:10]=1)(=[O:4])=[O:3].[ClH:13].[H][H]>CO.[Pd]>[ClH:13].[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][NH2:12])=[N:9][CH:10]=1)(=[O:4])=[O:3]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 591699295-(Methylsulfonyl)pyridine-2-carbonitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 66725223[5-(Methanesulfonyl)pyridin-2-yl]methanaminium chloride収率 89%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

5-(Methylsulfonyl)pyridine-2-carbonitrile (2.15 g, 11.8 mmol) was dissolved in methanol (230 ml). 6M HCl (1 ml) and 10% palladium on carbon (2.34 mg) were added and the mixture was stirred under an atmospheric pressure of hydrogen overnight. The catalyst was removed by filtration through celite and the solvent was evaporated, water was added and the solution was freeze-dried to afford the title compound as a yellow powder (2.34 g, 89%).

後処理

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was evaporated
  3. additionwater was added
  4. customthe solution was freeze-dried

出典と根拠

ORDレコード
ord-7357e64aaf5d464b8a870f42cac42a69
出典データセット
uspto-grants-2013_08
特許番号
US08501784B2

反応ノート

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