Thionyl Chloride → 2,3-Dichloro-4-methylbenzoyl chloride

HRID 1889020ノート

反応式

HRID 1889020 の反応式
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 534304632,3-Dichloro-4-methylbenzoic acid

生成物 1

HCID 866667402,3-Dichloro-4-methylbenzoyl chloride収率 100%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2,3-Dichloro-4-methylbenzoic acid (I70) (5.90 g, 26.2 mmol) and thionyl chloride (30 mL, 411 mmol) were heated at 85° C. for 4 hr in toluene (100 mL). The solvents were removed in vacuo and the residue was azeotroped with toluene (3×100 mL). The residue was used in subsequent steps without further purification assuming 100% yield. Compound not characterised at this step.

後処理

  1. customThe solvents were removed in vacuo
  2. customthe residue was azeotroped with toluene (3×100 mL)
  3. customThe residue was used in subsequent steps without further purification

出典と根拠

ORDレコード
ord-0b4f10b90a43412d8a4e0eb289a0de2d
出典データセット
uspto-grants-2013_08
特許番号
US08501946B2

反応ノート

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