Hydrazine hydrate (1:1) → 2-Oxo-1,2-dihydropyridine-3-carbohydrazide
反応式
O.[NH2:2][NH2:3].[OH:4][C:5]1[C:10]([C:11]([O:13]C)=O)=[CH:9][CH:8]=[CH:7][N:6]=1>C(O)C>[O:4]=[C:5]1[C:10]([C:11]([NH:2][NH2:3])=[O:13])=[CH:9][CH:8]=[CH:7][NH:6]1参加物
4
実験手順
Hydrazine hydrate (0.192 mL, 3.92 mmol) was added to a solution of the methyl 2-hydroxy-3-pyridinecarboxylate (400 mg, 2.61 mmol, commercially available from e.g. Apollo or Butt Park) in ethanol (10 mL) and the reaction was heated to reflux for 16 hrs. The reaction was cooled and the solvent was evaporated to afford an off-white solid in 395 mg.
後処理
- temperatureto reflux for 16 hrs
- temperatureThe reaction was cooled
- customthe solvent was evaporated
- customto afford an off-white solid in 395 mg
出典と根拠
- ORDレコード
- ord-031795ea8d9744fd811b0b87a5eebc37
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08501946B2
反応ノート
読み込み中…