Hydrazine hydrate (1:1) → HCID 178428523、化合物
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[N:3]=1.O.[NH2:11][NH2:12]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8](=[NH:9])[NH:11][NH2:12])[N:3]=1参加物
4
実験手順
4-methyl-2-pyrimidinecarbonitrile (I98)(0.190 g, 1.595 mmol) was dissolved in ethanol (3.19 ml) and hydrazine hydrate (0.100 ml, 3.19 mmol) was added. The reaction mixture was left at reflux for 2.5 hours. TLC showed that no starting material remained so the solvent was removed under reduced pressure to afford the crude desired product in 247 mg.
後処理
- waitThe reaction mixture was left
- temperatureat reflux for 2.5 hours
- customwas removed under reduced pressure
出典と根拠
- ORDレコード
- ord-1e337ac954234acbb6d2f95036a7e422
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08501946B2
反応ノート
読み込み中…