Trifluoroacetic acid → 6-Amino-hexanoic acid {4-[3-(4-tert-butyl-benzoyl)-thioureido]-phenyl}-amide trifluoroacetate
反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[O:37])[NH:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][C:29]([C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=[S:23])=[CH:17][CH:16]=1)(C)(C)C.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>C(Cl)Cl>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[C:32]([C:29]1[CH:28]=[CH:27][C:26]([C:25]([NH:24][C:22](=[S:23])[NH:21][C:18]2[CH:19]=[CH:20][C:15]([NH:14][C:13](=[O:37])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][NH2:7])=[CH:16][CH:17]=2)=[O:36])=[CH:31][CH:30]=1)([CH3:35])([CH3:33])[CH3:34]参加物
4
実験手順
Boc protected amine 32 (20 mg, 0.04 mmol) was stirred in CH2Cl2 (1 mL) and trifluoroacetic acid (166 μL) at rt for 30 min. Concentration in vacuo gave 33 as a pale yellow oil.