Ethyl chloroformate → Methyl 2-[(ethoxycarbonyl)amino]-5-ethylthiophene-3-carboxylate
反応式
[NH2:1][C:2]1[S:3][C:4]([CH2:11][CH3:12])=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].Cl[C:14]([O:16][CH2:17][CH3:18])=[O:15]>C1(C)C=CC=CC=1>[CH2:17]([O:16][C:14]([NH:1][C:2]1[S:3][C:4]([CH2:11][CH3:12])=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8])=[O:15])[CH3:18]参加物
4
反応条件
- 温度
- 100 °C
実験手順
A mixture of methyl 2-amino-5-ethylthiophene-3-carboxylate (7.07 g), ethyl chloroformate (4.4 mL) and toluene (100 mL) was stirred at 100° C. for 3 hr. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography to give the title compound as colorless oil (9 g, 92%).
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe obtained residue was purified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-f6cad9811457482fb2f981cfae7d4920
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08501750B2
反応ノート
読み込み中…