HCID 178526704、化合物 → HCID 178507771、化合物
反応式
[CH:1]1([NH:7][C:8]2[N:13]=[C:12]([OH:14])[CH:11]=[CH:10][C:9]=2[N+:15]([O-])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CO.[Pd]>[NH2:15][C:9]1[CH:10]=[CH:11][C:12]([OH:14])=[N:13][C:8]=1[NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
6-(Cyclohexylamino)-5-nitropyridin-2-ol (0.2 g, 0.843 mmol) was dissolved in methanol (168 mL). Palladium (5% Pd/C, 145 mg, 0.0063 mmol) was added. The reaction was flushed with nitrogen and stirred under a balloon filled with hydrogen for 3 h at room temperature. The reaction was monitored by TLC until the starting materials were consumed. The mixture was filtered through Celite® and concentrated to give the title compound as a dark green solid which was used immediately in next step without further purification.
後処理
- customThe reaction was flushed with nitrogen
- additionfilled with hydrogen for 3 h at room temperature
- customwere consumed
- filtrationThe mixture was filtered through Celite®
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-fcfd0c686800469fbeb754eed37849fd
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507473B2
反応ノート
読み込み中…