Methanol → thieno[3,2-b]pyridin-2-ylmethanol
反応式
[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](OC)=[O:11].[H-].[H-].[H-].[H-].[Li+].[Al+3].CO>C1COCC1>[S:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[CH2:10][OH:11]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a solution of methyl thieno[3,2-b]pyridine-2-carboxylate (C-3) (600 mg, 3.1 mmol) in 30 mL of anhydrous THF at 0° C. was added LiAlH4 (472 mg, 12.4 mmol) in anhydrous THF (25 mL) dropwise over 20 mins. The reaction mixture was stirred at 0° C. for 30 mins. MeOH was added and the resulting mixture was purified by chromatography to afford the title compound. MS (m/z): 166 (M+1)+.
後処理
- customthe resulting mixture was purified by chromatography
出典と根拠
- ORDレコード
- ord-bb5c8674fc524f55a070a6ae1b4f1a90
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507487B2
反応ノート
読み込み中…