Aluminium lithium hydride → 1-(Thieno[3,2-c]pyridin-2-yl)ethan-1-ol

HRID 1890519ノート

反応式

HRID 1890519 の反応式
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10](=[O:12])[CH3:11].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[CH:10]([OH:12])[CH3:11]

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 584330461-(Thieno[3,2-c]pyridin-2-yl)ethanone

生成物 1

HCID 673049441-(Thieno[3,2-c]pyridin-2-yl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-(thieno[3,2-c]pyridin-2-yl)ethanone (D′-3) (3.5 g, 1 mmol) in anhydrous THF (50 mL) was added LiAlH4 (1.13 g, 1.5 mmol) in portions at 0° C. The suspension was stirred under this temperature for 1 h. The reaction mixture was quenched with saturated aqueous NH4Cl solution and filtered. The filtrate was washed with brine, concentrated, and then used for the next step without any further purification.

後処理

  1. customThe reaction mixture was quenched with saturated aqueous NH4Cl solution
  2. filtrationfiltered
  3. washThe filtrate was washed with brine
  4. concentrationconcentrated
  5. customused for the next step without any further purification

出典と根拠

ORDレコード
ord-596329c447e34f76b860f4f8ff482604
出典データセット
uspto-grants-2013_08
特許番号
US08507487B2

反応ノート

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