methyl 3-acetyl-6-chloro-1H-indole-5-carboxylate → 3-acetyl-6-chloro-1H-indole-5-carboxylic acid

HRID 1891019ノート

反応式

HRID 1891019 の反応式
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([Cl:17])=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=2)[NH:6][CH:5]=1)(=[O:3])[CH3:2]>[OH-].[Na+].O1CCOCC1>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([Cl:17])=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=2)[NH:6][CH:5]=1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 67774875methyl 3-acetyl-6-chloro-1H-indole-5-carboxylate

生成物 1

HCID 677727683-acetyl-6-chloro-1H-indole-5-carboxylic acid収率 96%

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of methyl 3-acetyl-6-chloro-1H-indole-5-carboxylate (0.21 g, 0.84 mmol) in 1.5 N sodium hydroxide (0.7 mL) and dioxane (0.5 mL) was heated at 60 C for 6 h and stirred overnight at room temperature. The reaction was quenched by the addition of acetic acid and diluted with water. The resulting solid was filtered, washed with water and dried in vacuo to give the title compound (0.17 g, 96%) as pale yellow powder, m/z=238 (M+H).

後処理

  1. customThe reaction was quenched by the addition of acetic acid
  2. additiondiluted with water
  3. filtrationThe resulting solid was filtered
  4. washwashed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-16c9e3526619438c92b2f5f37701ded0
出典データセット
uspto-grants-2013_08
特許番号
US08507499B2

反応ノート

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