Tetrahydrofuran → 4-(Methylamino)-2-(methylthio)pyrimidine-5-carbonitrile
反応式
CN.CO.[CH2:5]([N:7](CC)CC)C.O1CCCC1.Cl[C:18]1[C:23]([C:24]#[N:25])=[CH:22][N:21]=[C:20]([S:26][CH3:27])[N:19]=1>O>[CH3:5][NH:7][C:18]1[C:23]([C:24]#[N:25])=[CH:22][N:21]=[C:20]([S:26][CH3:27])[N:19]=1参加物
6
実験手順
3 ml of a methylamine-methanol solution, and 246 mg of triethylamine were added to a tetrahydrofuran (10 mL) solution containing 150 mg of 4-chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile, and the mixture was stirred for 30 minutes at room temperature. After adding water, the solution was extracted with ethyl acetate, and dried with anhydrous magnesium sulfate. After concentration, 134 mg of a white solid was obtained as a subject compound.
後処理
- extractionthe solution was extracted with ethyl acetate
- dry with materialdried with anhydrous magnesium sulfate
- concentrationAfter concentration
出典と根拠
- ORDレコード
- ord-9f8fa8b662f9434ba8143bae925f26f2
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507505B2
反応ノート
読み込み中…