Water → 1-(2,4-Bis-benzyloxy-5-bromo-phenyl)-ethanone

HRID 1891154ノート

反応式

HRID 1891154 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[C:23](=[O:25])[CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:26]N1C(=O)CCC1=O.O>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:12]([Br:26])=[CH:11][C:10]=1[C:23](=[O:25])[CH3:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 3194691-(2,4-Bis(benzyloxy)phenyl)ethanone

生成物 1

HCID 247744411-(2,4-Bis-benzyloxy-5-bromo-phenyl)-ethanone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

51.2 g of 1-(2,4-Bis-benzyloxy-phenyl)ethanone (0.154 mol, 1 eq) were dissolved in 250 ml DMF. 27.42 g N-bromosuccinimide (0.154 mol, 1 eq) in 100 ml DMF were added dropwise. The mixture was stirred at room temperature over night. The reaction mixture was poured onto 700 ml of water and the precipitate filtered off. The filter cake was rinsed with water and the colourless solid was recrystallised from 370 ml acetonitrile.

後処理

  1. filtrationthe precipitate filtered off
  2. washThe filter cake was rinsed with water
  3. customthe colourless solid was recrystallised from 370 ml acetonitrile

出典と根拠

ORDレコード
ord-130b7b61dbdf4b4e90f7b85974eb3a98
出典データセット
uspto-grants-2013_08
特許番号
US08507480B2

反応ノート

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