Hydrochloric Acid → HCID 59637736、化合物
反応式
C([OH:4])C#C.[Br:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].Cl.N1C=C[CH:18]=[CH:17][CH:16]=1>C1C=CC=CC=1>[Br:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:12][CH2:16][C:17]#[CH:18])=[O:4]参加物
6
実験手順
Propargyl alcohol (0.5 mL, 3.41 mmol, 1 eq.) was dissolved in 10 mL of dry pyridine and 10 mL of dry benzene under argon and this solution was cooled in an ice bath. 6-bromohexanoyl chloride (0.612 mL, 4.1 mmol, 1.2 eq.) dissolved in 10 mL of dry benzene under argon was then added dropwise to the propargyl alcohol solution and stirred overnight. The solution was acidified with 1M HCl, then extracted twice with CH2Cl2. The organic layers were twice washed with 1M NaOH, once washed with brine, and dried over Na2SO4. The solvent was removed on a rotary evaporator to yield a light brown oil.
後処理
- extractionextracted twice with CH2Cl2
- washThe organic layers were twice washed with 1M NaOH
- washonce washed with brine
- dry with materialdried over Na2SO4
- customThe solvent was removed on a rotary evaporator
- customto yield a light brown oil
出典と根拠
- ORDレコード
- ord-64deded968c14208b508c33660135e30
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08507572B2
反応ノート
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