Dimethylformamide → HCID 14990310、化合物

HRID 1892078ノート

反応式

HRID 1892078 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].CN(C=O)C.[CH2:12]([C:17]1[CH:22]=[CH:21][C:20](/[C:23](/C)=[CH:24]/C(O)=O)=[CH:19][CH:18]=1)[CH2:13][CH2:14][CH2:15][CH3:16]>ClCCl>[CH2:12]([C:17]1[CH:22]=[CH:21][C:20](/[C:23](/[CH3:24])=[CH:1]/[C:2]([Cl:4])=[O:3])=[CH:19][CH:18]=1)[CH2:13][CH2:14][CH2:15][CH3:16]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6083612(E)-3-(4-pentylphenyl)but-2-enoic acid

生成物 1

HCID 14990310HCID 14990310、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Oxalyl chloride (3.2 mL, 36.60 mmol) and DMF (50 μL) were added drop wise to a solution of compound 1003 (5.0 g, 21.52 mmol) in dichloromethane (100 mL) at 0° C. The reaction solution was warmed up to room temperature and stirred for 4 hours. The reaction mixture was concentrated in vacuum and the residue was dried under hi-vacuum for 3 hours. The crude product was used in the next step without further purification.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuum
  2. customthe residue was dried under hi-vacuum for 3 hours
  3. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-d1071c2591134443bbc82c1b96380fd9
出典データセット
uspto-grants-2013_08
特許番号
US08507647B2

反応ノート

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