4-(4-Isopropylphenyl)butanoic acid → HCID 59409743、化合物

HRID 1892093ノート

反応式

HRID 1892093 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>C(O)(=O)C.O=[Pt]=O>[CH:1]([CH:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 3476744-(4-Isopropylphenyl)butanoic acid

生成物 1

HCID 59409743HCID 59409743、化合物収率 107.9%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 176Acetic Acid溶媒

実験手順

A suspension of compound 77 (1.0 g, 4.8 mmol) and 0.1 g of PtO2 in 50 mL of acetic acid was stirred under a H2 atmosphere (50 psi) at ambient temperature for 6 hours. After filtering and evaporating off the solvent, 1.1 g crude product was obtained. The compound was used directly in the next step without further purification. LC-MS m/z 211 (M−H+).

後処理

  1. filtrationAfter filtering
  2. customevaporating off the solvent

出典と根拠

ORDレコード
ord-fc6f5632061a4f348c6ca76e3648c2a0
出典データセット
uspto-grants-2013_08
特許番号
US08507647B2

反応ノート

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