Triethylamine → 1-Heptyl-4-isocyanatobenzene

HRID 1892094

反応式

HRID 1892094 の反応式
[CH2:1]([C:8]1[CH:16]=[CH:15][C:11](C(O)=O)=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].CC[N:19]([CH2:22]C)CC.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:31])C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]([N:19]=[C:22]=[O:31])=[CH:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 170036Benzoic acid, 4-heptyl-HCID 199401P,P-Diphenylphosphinic azide

生成物 1

HCID 594097981-Heptyl-4-isocyanatobenzene

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a degassed solution of 4-heptylbenzoic acid (3.0 g, 13.6 mmol) in anhydrous toluene (30 mL) and Et3N (3 mL, 21.5 mmol), was added diphenyl phosphoryl azide (2 mL, 9.3 mmol) dropwise. After completion of the addition, the reaction mixture was heated to reflux and stirred for 2 hours. The mixture was concentrated to dryness under reduced pressure to give the product, 1-heptyl-4-isocyanatobenzene (79), as an oil, which was used directly in the next reaction without further purification.

後処理

  1. additionAfter completion of the addition
  2. temperaturethe reaction mixture was heated
  3. temperatureto reflux
  4. concentrationThe mixture was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-fb51dda54e704621bcbae391cff51a49
出典データセット
uspto-grants-2013_08
特許番号
US08507647B2

関連ノート

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