2-Methyl-5-nitrobenzoic acid → 5-{[(2R)-2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino-}-2-methylbenzoic acid
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:22][C:23]2[CH:24]=[C:25]([C:28]([OH:30])=[O:29])N[CH:27]=2)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.[N+]([C:40]1[CH:41]=C(C(O)=O)N[CH:44]=1)([O-])=O.CC1C=CC([N+]([O-])=O)=CC=1C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:22][C:23]2[CH:27]=[CH:44][C:40]([CH3:41])=[C:25]([CH:24]=2)[C:28]([OH:30])=[O:29])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1参加物
4
反応物 3
生成物 1
実験手順
Instead of the starting material compound of Example 262, that is, the 4-nitropyrrole-2-carboxylic acid, 2-methyl-5-nitrobenzoic acid was used for the similar procedure as in Example 262 to obtain the title compound.