4-{4-[2-(4-Pentyl-cyclohexyl)-ethenyl]-phenyl}cyclohexane carboxylic acid methyl ester → 4-{4-[2-(4-Pentyl-cyclohexyl)-ethyl]-phenyl}-cyclohexane carboxylic acid methyl ester

HRID 1893077ノート

反応式

HRID 1893077 の反応式
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:16]=[CH:15][C:14]([CH:17]=[CH:18][CH:19]3[CH2:24][CH2:23][CH:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:21][CH2:20]3)=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)=[O:4]>C1(C)C=CC=CC=1.C(O)C.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH2:6][CH2:7][CH:8]([C:11]2[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][CH:19]3[CH2:20][CH2:21][CH:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:23][CH2:24]3)=[CH:15][CH:16]=2)[CH2:9][CH2:10]1)=[O:4]

参加物

5

反応物 1

HCID 584532174-{4-[2-(4-Pentyl-cyclohexyl)-ethenyl]-phenyl}cyclohexane carboxylic acid methyl ester

生成物 1

HCID 584532084-{4-[2-(4-Pentyl-cyclohexyl)-ethyl]-phenyl}-cyclohexane carboxylic acid methyl ester収率 88%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒2 回HCID 702Ethanol溶媒HCID 1140Toluene溶媒

実験手順

6.9 g (17.4 mmol) of 4-{4-[2-(4-pentyl-cyclohexyl)-vinyl]-phenyl}cyclohexane carboxylic acid methyl ester produced in Example 6-1 was dissolved in a mixture of toluene and ethanol (1:1 by volume %). 0.4 g of Pd/C was added to 200 mL of the resultant solution and reacted in hydrogenation reactor for 12 hours. After reaction, Pd/C was removed by filtration, concentrated under reduced pressure and recrystallized from chloroform and ethanol to obtain 6.1 g (88%) of 4-{4-[2-(4-pentyl-cyclohexyl)-ethyl]-phenyl}-cyclohexane carboxylic acid methyl ester.

後処理

  1. customreacted in hydrogenation reactor for 12 hours
  2. customwas removed by filtration
  3. concentrationconcentrated under reduced pressure
  4. customrecrystallized from chloroform and ethanol

出典と根拠

ORDレコード
ord-0091151366e44444b24dc1fd0e3e3bcd
出典データセット
uspto-grants-2013_08
特許番号
US08512598B2

反応ノート

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