Trifluoroacetic acid → (4-Phenyl-cyclohexyl)-azetidin-3-ylamine TFA Salt

HRID 1893300

反応式

HRID 1893300 の反応式
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(O[C:13](=O)[NH:14][CH:15]1C[N:17]([CH:19]2[CH2:24][CH2:23][CH:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:21][CH2:20]2)[CH2:16]1)(C)(C)C>>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[C:25]1([CH:22]2[CH2:23][CH2:24][CH:19]([NH:17][CH:16]3[CH2:13][NH:14][CH2:15]3)[CH2:20][CH2:21]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 59541918[1-(4-Phenyl-cyclohexyl)-azetidin-3-yl]-carbamic acid tert-butyl ester

生成物 1

HCID 86646680(4-Phenyl-cyclohexyl)-azetidin-3-ylamine TFA Salt

実験手順

The title compound was prepared as colorless oil from the TFA de-protection of [1-(4-phenyl-cyclohexyl)-azetidin-3-yl]-carbamic acid tert-butyl ester (as prepared in the previous step) using the procedure described in Step E of Example 1.

後処理

  1. customas prepared in the previous step)

出典と根拠

ORDレコード
ord-5a3ca7c057f6405d837d155fb0caf671
出典データセット
uspto-grants-2013_08
特許番号
US08513229B2

関連ノート

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