Hydrochloric Acid → HCID 57445190、化合物

HRID 1893689ノート

反応式

HRID 1893689 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][CH:12]([CH3:14])[CH3:13])[O:9][CH:10]=1)=[O:5])C.[OH-].[Na+].Cl>CCO.O>[CH:12]([NH:11][C:8]1[O:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1)([CH3:14])[CH3:13]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57445189HCID 57445189、化合物

生成物 1

HCID 57445190HCID 57445190、化合物収率 100.3%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To 2-isopropylamino-oxazole-4-carboxylic acid ethyl ester (2.5 g, 10.9 mmol) in EtOH (42 mL) and water (28 mL) was added NaOH (3.1 g, 77.4 mmol). The mixture was stirred at rt for 16 h, then cooled in an ice-bath and acidified to pH 3 with conc. HCl. The mixture was concentrated in vacuo to remove ethanol. The remaining aqueous phase was extracted with CH2Cl2 (3×200 mL). The organic phases were combined, dried over MgSO4 and concentrated to give 2-isopropylaminooxazole-4-carboxylic acid (1.86 g, 87% yield). LCMS found 171 [M+H]+.

後処理

  1. temperaturecooled in an ice-bath
  2. concentrationThe mixture was concentrated in vacuo
  3. customto remove ethanol
  4. extractionThe remaining aqueous phase was extracted with CH2Cl2 (3×200 mL)
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-e8cb122e38ef48dcad8d50e719699a2c
出典データセット
uspto-grants-2013_08
特許番号
US08513186B2

反応ノート

読み込み中…