反応式
[C:1]([C:5]1[NH:6][C:7]([N+:21]([O-])=O)=[C:8]([C:10]([N:12]2[CH2:17][CH2:16][NH:15][C:14](=[O:18])[C:13]2([CH3:20])[CH3:19])=[O:11])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:21][C:7]1[NH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:9][C:8]=1[C:10]([N:12]1[CH2:17][CH2:16][NH:15][C:14](=[O:18])[C:13]1([CH3:19])[CH3:20])=[O:11]参加物
4
実験手順
To 4-(2-tert-butyl-5-nitro-1H-pyrrole-4-carbonyl)-3,3-dimethylpiperazin-2-one (120 mg) in methanol (10 mL) was added Pd catalyst (10% on carbon, 60 mg) and the resulting reaction mixture was stirred under H2 at 60 psi for overnight. After the solids were removed by filtration over Celite, the solvent was removed in vacuo to afford 4-(2-amino-5-tert-butyl-1H-pyrrole-3-carbonyl)-3,3-dimethylpiperazin-2-one 7 as a yellow film (100 mg, 92%).
後処理
- customthe resulting reaction mixture
- customAfter the solids were removed by filtration over Celite
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-51c3ecd5f60144d39cf31500a3d542e9
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741479B2
関連ノート
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