Sodium Hydroxide → 4-(2-ethyl-1-(1H-imidazol-1-yl)butyl)aniline

HRID 1894769ノート

反応式

HRID 1894769 の反応式
[CH2:1]([CH:3]([CH2:20][CH3:21])[CH:4]([C:10]1[CH:15]=[CH:14][C:13]([NH:16]C(=O)C)=[CH:12][CH:11]=1)[N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1)[CH3:2].[OH-].[Na+]>Cl>[CH2:20]([CH:3]([CH2:1][CH3:2])[CH:4]([C:10]1[CH:11]=[CH:12][C:13]([NH2:16])=[CH:14][CH:15]=1)[N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1)[CH3:21]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86681896N-(4-(2-ethyl-1-(1H-imidazol-1-yl)butyl)phenyl)acetamide

生成物 1

HCID 866818974-(2-ethyl-1-(1H-imidazol-1-yl)butyl)aniline

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of N-(4-(2-ethyl-1-(1H-imidazol-1-yl)butyl)phenyl)acetamide (350 mg, 1.23 mmol) in 3N HCl (3.28 mL) was stirred overnight at 60° C. After cooling to room temperature, the solution was poured onto ice and basified with 6N NaOH (pH=12-14). The aqueous phase was extracted three times with DCM and the organic extracts were combined and dried over MgSO4, filtered and then concentrated to afford to 4(2-ethyl-1-(1H-imidazol-1-yl)butyl)aniline. MS (ES+): m/z 244.31 (MH+).

後処理

  1. additionthe solution was poured onto ice
  2. extractionThe aqueous phase was extracted three times with DCM
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-70583211e1614cd4bf56ff28e0c07f0d
出典データセット
uspto-grants-2013_08
特許番号
US08513291B2

反応ノート

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