Formaldehyde → Ethyl (1-phenyl-1,3-diazaspiro[4.5]dec-3-yl)acetate
反応式
[C:1]1([NH:7][C:8]2([CH2:14][NH:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:22]=O>ClCCl>[C:1]1([N:7]2[C:8]3([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]3)[CH2:14][N:15]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:22]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
510 mg (1.75 mmol) of ethyl [(1-phenylaminocyclohexylmethyl)amino]-acetate are dissolved in 10 ml of dichloromethane and 10 ml of formaldehyde are added. The solution is heated to 100° C. with microwaves for 30 min. The medium is poured into dichloromethane and washed with water. The organic phases are collected and then dried over sodium sulfate. The solvents are evaporated. 520 mg of ethyl (1-phenyl-1,3-diazaspiro[4.5]dec-3-yl)acetate are obtained in the form of a colorless oil. Yield=98%.