HCID 67646998、化合物 → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1895ノート

反応式

HRID 1895 の反応式
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

参加物

4

反応物 1

HCID 67646998HCID 67646998、化合物

生成物 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine収率 35.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 atm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

後処理

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

出典と根拠

ORDレコード
ord-599ef965de604788a8f4493886ac4c46
出典データセット
uspto-grants-1998_03
特許番号
US05726182

反応ノート

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