Sodium Azide → 11-Azidoundecan-1-ol
反応式
Br[CH:2]([OH:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[N-:14]=[N+:15]=[N-:16].[Na+]>CN(C=O)C>[N:14]([CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:13])=[N+:15]=[N-:16]参加物
4
実験手順
To a 250 mL round-bottom dry flask was added anhydrous DMF (60 mL), 11 bromo-1-undecanol (10 g, 39.8 mmol) and NaN3 (2.85 g, 43.8 mmol). The solution was stirred with a magnetic bar for 24 hours at ambient temperature and quenched with DI water (60 mL). The solution was extracted with CH2Cl2 (3×40 mL), re-extracted with DI water (2×50 mL), dried with sodium sulfate overnight, and filtered. After the removal of the solvent by a rotoevaporator, a clear, colorless liquid (9.1 g, 93.4%) was obtained.
後処理
- customquenched with DI water (60 mL)
- extractionThe solution was extracted with CH2Cl2 (3×40 mL)
- extractionre-extracted with DI water (2×50 mL)
- dry with materialdried with sodium sulfate overnight
- filtrationfiltered
- customAfter the removal of the solvent by a rotoevaporator
出典と根拠
- ORDレコード
- ord-b0bf7db14d5e42bca5048f61140ae30c
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08518473B2
反応ノート
読み込み中…