HCID 58385972、化合物 → (1S,6R)-6-amino-2,2-difluorocyclohexanol
反応式
[F:1][C:2]1([F:18])[CH2:7][CH2:6][CH2:5][C@H:4]([NH:8][C@@H](C2C=CC=CC=2)C)[C@H:3]1[OH:17]>CO.[OH-].[OH-].[Pd+2]>[NH2:8][C@H:4]1[C@H:3]([OH:17])[C:2]([F:18])([F:1])[CH2:7][CH2:6][CH2:5]1参加物
4
実験手順
A solution of (1S,6R)-2,2-difluoro-6-{[(1R)-1-phenylethyl]amino}cyclohexanol 23 (2 g, 7.83 mmol) in methanol (100 mL) was degassed with nitrogen, treated with Pd(OH)2/C (0.55 g) and then placed under an atmosphere of hydrogen and stirred vigorously for 16 hours. The reaction was filtered, washing with methanol, and evaporated in vacuo to give 1.0 g (84%) of (1S,6R)-6-amino-2,2-difluorocyclohexanol 24 as a white solid: 1H NMR (500 MHz, CD3OD) δ 3.34 (1H, m), 2.74 (1H, m), 2.07 (1H, m), 1.89 (1H, m), 1.73 (2H, m), 1.50 (1H, m), 1.27 (1H, m).
後処理
- filtrationThe reaction was filtered
- washwashing with methanol
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-a5c876e577b6426886f5fef099ceba5d
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08518911B2
反応ノート
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