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3-Fluoro-4-nitroanisole → 2-{3-[1-(5-Methoxy-2-nitrophenyl)piperidin-4-ylidene]prop-1-ynyl}-6-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Fluoro-4-nitroanisole | HCID 565654 | — |
| 反応物 | 2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine | HCID 87550402 | — |
| 生成物 | 2-{3-[1-(5-Methoxy-2-nitrophenyl)piperidin-4-ylidene]prop-1-ynyl}-6-methylpyridine | HCID 25183672 | 48.2% |
反応手順
A well homogenised mixture of the Compound of Example 3 (20 mg, 0.93 mmol) and 2-fluoro-4-methoxynitrobenzene (21.3 mg, 0.12 mmol) was stirred at 120° C. for 0.5 h. The reaction crude was purified by flash chromatography (EtOAc—Petroleum Ether 1:1) affording the title product (21 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08518916B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-39a9851e51bb435f8577bb27293eea9e |
| 出典メモ | uspto-grants-2013_08 |