Adenine → 9-(3-chloropropyl)-9H-purin-6-amine

HRID 1896065ノート

反応式

HRID 1896065 の反応式
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:15][CH2:14][CH2:13][CH2:12][N:5]1[CH:6]=[N:7][C:8]2[C:4]1=[N:3][CH:2]=[N:1][C:9]=2[NH2:10]

参加物

5

反応物 3

HCID 190AdenineHCID 80061-Bromo-3-chloropropaneHCID 11430Potassium Carbonate

生成物 1

HCID 2865919-(3-chloropropyl)-9H-purin-6-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of adenine, 1-bromo-3-chloropropane, and potassium carbonate in DMF was stirred at room temperature under argon for 4 days, filtered and evaporated to dryness. The crude product was washed with water and dried. Recrystallization from ethanol gave 9-(3-chloropropyl)adenine.

後処理

  1. filtrationfiltered
  2. customevaporated to dryness
  3. washThe crude product was washed with water
  4. customdried
  5. customRecrystallization from ethanol

出典と根拠

ORDレコード
ord-ca790394ac114b64a4566e76a750bf06
出典データセット
uspto-grants-2013_08
特許番号
US08518885B2

反応ノート

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