Sodium Azide → 9-(3-Azidopropyl)adenine
反応式
Cl[CH2:2][CH2:3][CH2:4][N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2[NH2:14].[N-:15]=[N+:16]=[N-:17].[Na+]>CN(C=O)C>[N:15]([CH2:2][CH2:3][CH2:4][N:5]1[CH:13]=[N:12][C:11]2[C:6]1=[N:7][CH:8]=[N:9][C:10]=2[NH2:14])=[N+:16]=[N-:17]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 9-(3-chloropropyl)adenine and sodium azide in DMF was stirred at 80° C. for 24 hours, cooled to room temperature and filtered. The solid was washed with CH2Cl2. The solvent was removed from the combined filtrates and the residue was taken up in water with sonication. The aqueous layer was extracted with CH2Cl2. After removing the solvent, the crude product was recrystallized from ethanol to give 9-(3-azidopropyl)adenine as a white crystalline solid.
後処理
- temperaturecooled to room temperature
- filtrationfiltered
- washThe solid was washed with CH2Cl2
- customThe solvent was removed from the combined filtrates
- customthe residue was taken up in water with sonication
- extractionThe aqueous layer was extracted with CH2Cl2
- customAfter removing the solvent
- customthe crude product was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-dc8e8747d9b6443687f6f629e49ca7d3
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08518885B2
反応ノート
読み込み中…