1-(2-ethoxyethyl)-3-ethyl-4-nitro-1H-pyrazole-5-carboxamide → 4-amino-1-(2-ethoxyethyl)-3-ethyl-1H-pyrazole-5-carboxamide

HRID 1896198

反応式

HRID 1896198 の反応式
[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[C:10]([C:11]([NH2:13])=[O:12])=[C:9]([N+:14]([O-])=O)[C:8]([CH2:17][CH3:18])=[N:7]1)[CH3:2].[H][H]>[Pt].C(OC(C)C)(=O)C>[NH2:14][C:9]1[C:8]([CH2:17][CH3:18])=[N:7][N:6]([CH2:5][CH2:4][O:3][CH2:1][CH3:2])[C:10]=1[C:11]([NH2:13])=[O:12]

参加物

5

反応物 2

HCID 577445561-(2-ethoxyethyl)-3-ethyl-4-nitro-1H-pyrazole-5-carboxamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 577445394-amino-1-(2-ethoxyethyl)-3-ethyl-1H-pyrazole-5-carboxamide

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 7915Isopropyl Acetate溶媒

実験手順

1-(2-ethoxyethyl)-3-ethyl-4-nitro-1H-pyrazole-5-carboxamide from step 1 (15.0 g, 58 mmol), 5% Platinum-on-carbon (0.75 g), and isopropyl acetate (150 mL) were combined and the mixture was stirred under 80 psi of hydrogen for about 50 hours. The mixture was then filtered through celite, the celite was rinsed with acetonitrile, and the filtrate was concentrated. The material eventually crystallized to give 13.7 g as a hydrate of the title compound.

後処理

  1. filtrationThe mixture was then filtered through celite
  2. washthe celite was rinsed with acetonitrile
  3. concentrationthe filtrate was concentrated
  4. customThe material eventually crystallized

出典と根拠

ORDレコード
ord-fe48cc5037154e5db3225d1bb8c24ee2
出典データセット
uspto-grants-2013_08
特許番号
US08518956B2

関連ノート

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