Ammonia → 2-(4-Methoxyphenyl)acetamide

HRID 1896240ノート

反応式

HRID 1896240 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.S(Cl)(Cl)=O.[NH3:17]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([NH2:17])=[O:12])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 76904-Methoxyphenylacetic AcidHCID 24386Thionyl Chloride

生成物 1

HCID 2418682-(4-Methoxyphenyl)acetamide収率 70%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 2-(4-methoxyphenyl)acetic acid (500 mg, 3.00 mmol) in DCM (30 ml) was added thionyl chloride (0.4 ml, 4.5 mmol) at 0° C. The reaction mixture was allowed to warm up to room temperature and continued to stirred overnight. Then aqueous ammonia (2 ml) was added to the reaction mixture. The white solid forming was filtered and dried under vacuum to obtained 350 mg (70%) of 2-(4-methoxyphenyl)acetamide as a white solid.

後処理

  1. customThe white solid forming
  2. filtrationwas filtered
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-5ad97b8f130c4fa1b36f0b06d47086ca
出典データセット
uspto-grants-2013_08
特許番号
US08518948B2

反応ノート

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