Water → 3-[6-(2-Fluorophenyl)pyridin-3-yl]propan-1-ol

HRID 1896692ノート

反応式

HRID 1896692 の反応式
C([O:3][C:4](=O)[CH2:5][CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])=[CH:11][CH:12]=1)C.[BH4-].[Li+].O>C1COCC1>[F:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:10]1[N:9]=[CH:8][C:7]([CH2:6][CH2:5][CH2:4][OH:3])=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 962WaterHCID 4148881Lithium borohydrideHCID 68537058Ethyl 3-[6-(2-fluorophenyl)pyridin-3-yl]propanoate

生成物 1

HCID 691058943-[6-(2-Fluorophenyl)pyridin-3-yl]propan-1-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Under argon, 400 mg (1.46 mmol) of 3-(6-(2-fluorophenyl)pyridin-3-yl)propionic acid ethyl ester and 63.8 mg (2.93 mmol) of lithium borohydride were stirred in 20 ml of THF at 40° C. for 3 h. After cooling, the mixture was cautiously hydrolyzed with water, the precipitate was filtered off with suction, and water and methylene chloride were added to the filtrate. The organic phase was separated, washed with water and concentrated. Yield: 241 mg (71%).

後処理

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered off with suction, and water and methylene chloride
  3. additionwere added to the filtrate
  4. customThe organic phase was separated
  5. washwashed with water
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-46c3041dae0141aaa168b5230838e062
出典データセット
uspto-grants-2013_08
特許番号
US08518976B2

反応ノート

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