Methanesulfonyl chloride → 3-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanyl methylsulfonyl ether

HRID 1897

反応式

HRID 1897 の反応式
[C:1]([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C@@H:13]([CH2:17][N+:18]([O-:20])=[O:19])[CH2:14][CH2:15][OH:16])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[CH3:21][S:22]([O:16][CH2:15][CH2:14][C@@H:13]([C@@H:9]1[CH2:10][CH2:11][CH2:12][N:8]1[C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:17][N+:18]([O-:20])=[O:19])(=[O:24])=[O:23]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 228695313-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanol

生成物 1

HCID 867503003-(R)-(1-BOC-2-(S)-pyrrolidinyl)-4-nitrobutanyl methylsulfonyl ether

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A 3.5 g sample of the alcohol from step 471a above was dissolved in 25 mL of methylene chloride and treated with methanesulfonyl chloride an TEA at 0° C. for 2 hours. The reaction mixture was washed with NaHCO3 solution and water, and the solvent was removed. The residue was chromatographed on silica gel to give 3 g of the title compound.

後処理

  1. washThe reaction mixture was washed with NaHCO3 solution and water
  2. customthe solvent was removed
  3. customThe residue was chromatographed on silica gel

出典と根拠

ORDレコード
ord-d35336a8d63f46faa12cbe3c8194e4f3
出典データセット
uspto-grants-1998_03
特許番号
US05726182

関連ノート

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