Ethyl bromoacetate → 1-(2-Ethoxy-2-oxoethyl)-1-ethylpiperidin-1-ium bromide
反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)[CH3:2].[CH2:9]([O:11][C:12](=[O:15])[CH2:13][Br:14])[CH3:10]>ClCCl>[Br-:14].[CH2:9]([O:11][C:12](=[O:15])[CH2:13][N+:3]1([CH2:1][CH3:2])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)[CH3:10]参加物
4
実験手順
To a solution of 1-ethylpiperidine (2.5 g, 22.1 mmol) in dichloromethane (4 mL) was added ethylbromoacetate (3.7 g, 22.1 mmol) via a syringe. The mixture was stirred at room temperature overnight. The resulting white precipitate was washed with hexane and ethylacetate to give 6.1 g, 98.6% yield of the product as a white solid. Positive mode ESI/MS: m/z=200.4 (M+, minus Br); confirmed by 1H NMR.
後処理
- washThe resulting white precipitate was washed with hexane and ethylacetate
出典と根拠
- ORDレコード
- ord-b4686a9f058d409caf8bc5ca5987b92d
- 出典データセット
- uspto-grants-2013_08
- 特許番号
- US08519125B2
反応ノート
読み込み中…