Lithium hydroxide, monohydrate → HCID 57659748、化合物

HRID 1897556ノート

反応式

HRID 1897556 の反応式
[C:1]([C:5]1[S:9][C:8]([C:10]([O:12]CC)=[O:11])=[N:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].O.[OH-].[Li+:17]>C1COCC1.O>[C:1]([C:5]1[S:9][C:8]([C:10]([O-:12])=[O:11])=[N:7][N:6]=1)([CH3:4])([CH3:2])[CH3:3].[Li+:17]

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 2757341ethyl 5-tert-butyl-1,3,4-thiadiazole-2-carboxylate

生成物 1

HCID 57659748HCID 57659748、化合物収率 104.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of ethyl 5-tert-butyl-1,3,4-thiadiazole-2-carboxylate (0.21 g, 1.0 mmol) and lithium hydroxide hydrate (42 mg, 1.0 mmol) in THF (2 mL) and water (2 mL) was stirred at room temperature for 18 hours. The solvent was removed under vacuum to give lithium 5-tert-butyl-1,3,4-thiadiazole-2-carboxylate (0.2 g) as a white solid which was used without further purification.

後処理

  1. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-c18a0196ecd84d47aa546ae2a9eaba82
出典データセット
uspto-grants-2013_08
特許番号
US08519137B2

反応ノート

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