Trifluoroacetic acid → 3-Methylazetidine-3-carbonitrile; trifluoroacetic acid

HRID 1898507ノート

反応式

HRID 1898507 の反応式
C(OC([N:8]1[CH2:11][C:10]([C:13]#[N:14])([CH3:12])[CH2:9]1)=O)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[C:13]([C:10]1([CH3:12])[CH2:11][NH:8][CH2:9]1)#[N:14]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 56971684tert-Butyl 3-cyano-3-methylazetidine-1-carboxylate

生成物 1

HCID 673862343-Methylazetidine-3-carbonitrile; trifluoroacetic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-Cyano-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (0.23 g, 1.17 mmol) was dissolved in 12 mL of dichloromethane and the reaction was then stirred in an ice bath. Trifluoroacetic acid (3.6 mL) was added slowly and the solution was warmed to room temperature. After 3 h the reaction mixture was evaporated to afford 3-cyano-3-methyl-azetidine trifluoroacetate which was used without further purification.

後処理

  1. customAfter 3 h the reaction mixture was evaporated

出典と根拠

ORDレコード
ord-45e78b1486e74e1face942ff5f37f8b0
出典データセット
uspto-grants-2013_08
特許番号
US08518945B2

反応ノート

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