Trifluoroacetic acid → 1-((R)-2-amino-3,3-dimethylbutanoyl)-3-fluoropyrrolidine-3-carbonitrile trifluoroacetate
反応式
[C:1]([C:3]1([F:23])[CH2:7][CH2:6][N:5]([C:8](=[O:22])[C@H:9]([NH:14]C(=O)OC(C)(C)C)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:4]1)#[N:2].[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>C(Cl)Cl>[F:27][C:26]([F:29])([F:28])[C:24]([OH:30])=[O:25].[NH2:14][C@H:9]([C:10]([CH3:13])([CH3:12])[CH3:11])[C:8]([N:5]1[CH2:6][CH2:7][C:3]([F:23])([C:1]#[N:2])[CH2:4]1)=[O:22]参加物
4
実験手順
To a solution of tert-butyl (2R)-1-(3-cyano-3-fluoropyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate (234 mg, 0.72 mmol) in CH2Cl2 (5 mL) was added TFA (2.0 mL, 26.0 mmol). The reaction mixture was stirred at room temperature for 3 h then concentrated and dried under high vacuum to provide 1-((R)-2-amino-3,3-dimethylbutanoyl)-3-fluoropyrrolidine-3-carbonitrile trifluoroacetate as a pale yellow oil which was used without further purification.