Methyl 5-Acetoxy-2-formyl-4-methoxycinnamate → Methyl 5-Acetoxy-2-formyl-4-methoxyhydrocinnamate

HRID 1898761ノート

反応式

HRID 1898761 の反応式
[C:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([CH:17]=[O:18])=[C:9]([CH:16]=1)[CH:10]=[CH:11][C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([CH:17]=[O:18])=[C:9]([CH:16]=1)[CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 53756943Methyl 5-Acetoxy-2-formyl-4-methoxycinnamate

生成物 1

HCID 23372351Methyl 5-Acetoxy-2-formyl-4-methoxyhydrocinnamate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of methyl 5-acetoxy-2-formyl-4-methoxycinnamate (10.8 g) and 10% palladium on carbon (3 g) in ethyl acetate (100 ml) is hydrogenated at 45 psi for about 18 hours and filtered. The filtrate is concentrated in vacuo and the residue purified by HPLC, eluting 50% ethyl acetate in hexanes, to give the desired product.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate is concentrated in vacuo
  3. customthe residue purified by HPLC
  4. washeluting 50% ethyl acetate in hexanes

出典と根拠

ORDレコード
ord-d02b5e2cb1c64e93bd705cc8158c50d1
出典データセット
uspto-grants-1996_11
特許番号
US05571506

反応ノート

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