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Water → 2-(Propan-2-yl)benzene-1-sulfonyl fluoride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | 2-(Propan-2-yl)benzene-1-sulfonyl chloride | HCID 12916482 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-(Propan-2-yl)benzene-1-sulfonyl fluoride | HCID 23373130 | 96.1% |
反応手順
27 g of 2-isopropylbenzenesulfonyl chloride and 22 g of KF are stirred in 75 ml of dioxane and 20 ml of water at 45° C. for 27 h and at RT for 45 h. 800 ml of water are then added, and the mixture is extracted with 3×300 ml of EA. The combined organic phases are dried over Na2SO4 and the solvent is removed in vacuo. 24 g of a colorless oil are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05571842 |
| 出典データセット | uspto-grants-1996_11 |
| ORD ID | ord-f3291efbbab14b2a9a7fef2bd49b44d7 |
| 出典メモ | uspto-grants-1996_11 |